Assistant Research Professor
Virginia G. Piper Center for Personalized Diagnostics
The Biodesign Institute
Arizona State University
Doctor of Philosophy, Biological Design
Arizona State University, April 2015
Dissertation: "Ion Flux Regulates Inflammasome Signaling"
Bachelors of Science, Biological Sciences - Genetics, Cell and Developmental Biology
Arizona State University, May 2010
Summa cum laude
Barrett Honors College Thesis: "Automated Confocal Microscopy Assay: Studying Heterogeneity and Toxic Variability in Neoplastic Progression of Barrett's Esophagus Cells"
Virus-derived Immune Modulators
Co-evolution of viruses with their natural hosts invokes an adaptation arms race, where a successful strategy for the virus relies on immune evasion, often targeting key pathways that drive immune activation. Large DNA viruses, such as members of the poxvirus family, are adept at evading the innate immune system via a suite of virulence factors. Furthermore, because viruses are limited in their genomic space, it is common for immune modulating proteins to exhibit multipotent functionality, targeting numerous pathways simultaneously. Translationally, these factors constitute a rich toolbox for developing novel immune modulators.
I work with immune modulators from Myxoma virus, a poxvirus which is pathogenic in European rabbits but not in humans or rodents. Myxomavirus has evolved a highly efficient suite of multipotent immune modulators which target a wide array of pathways involved in immune response. A number of these immune modulators have already proven effective in rodent models of disease as well as in clinical trials in humans.