The Biodesign Institute at Arizona State University
2015, Ph.D. in Biological Design
Arizona State University
2010, B.S. in Biological Sciences (Genetics, Cell and Developmental Biology)
Arizona State University, Summa cum laude
I am a cell/molecular biologist developing novel therapeutics using immune modulators found in nature.
Currently, I am working with immune modulators from myxomavirus, a poxvirus which is pathogenic in European rabbits but not in humans or rodents. Myxomavirus has evolved a highly efficient suite of multipotent immune modulators which provide a rich toolbox for developing new therapeutic biologics.
Selected peer-reviewed publications with myxomavirus-derived immune modulators:
- Zhang L†, Yaron JR†, Tafoya AM, Wallace SE, Kilbourne J, Haydel S, Rege K, McFadden G, Lucas AR (2019). A virus-derived immune modulating SERPIN accelerates wound closure with improved collagen remodeling. J Clinical Medicine. 8(1626), 1-17 (†Equal Contributions)
- Yaron JR†, Chen H†, Ambadapadi S†, Zhang L, Tafoya AM, Munk BH, Wakefield D, Fuentes J, Marques BJ, Harripersaud K, Bartee MY, Davids J, Zheng D, Rand K, Dixon L, Moyer R, Clapp W, Lucas AR (2019). Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice. J. Inflamm. 16(1), 12 (†Equal Contributions)
- Kwiecien JM, Dabrowski W, Marzec-Kotarska B, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Lucas AR (2019). Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model. Folia Neuropathologica. 57(1), 41-50
- Chen H, Ambadapadi S, Wakefield D, Bartee MY, Yaron JR, Zhang L, Archer-Hartmann SA, Azadi P, Burgin M, Borges C, Zheng D, Ergle K, Muppala V, Morshed S, Rand K, Clapp W, Proudfoot A, Lucas A (2018). Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Scientific Reports. 8(1), 13433
- Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR (2018). Crystal Structure of Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function. Biochemistry. 57(7), 1096-1107
- Al-Ani M†, Ambadapadi S†, Yaron JR†, Zheng D, Fortunel A, Doroton-Guevara M, Liu L, Morshed S, Fricker J, Miles W, McKillop M, Lucas A (2017). Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation. Cardiovasc Hematol Disord Drug Targets. 17(3), 195-204 (†Equal Contributions)