Research Interests

Virus-Derived Immune Modulators

In order to become effective pathogens, viruses have evolved exceptionally capable immunomodulatory proteins specifically for circumventing anti-viral immune mechanisms. In many cases, these immunomodulators display cross-species activity and can be "repurposed" as anti-inflammatory "drugs" for treating inflammatory diseases in humans. In effect, we can take advantage of the hundreds of millions of years of R&D that viruses have invested.

Inflammasome Regulation

The inflammasome is a multi-protein, caspase-1-activating complex which drives the primary innate immune inflammatory response. Inflammasome activation is triggered by a wide variety of stimuli, thus inflammasomes are associated with a wide variety of diseases (both sterile, as in myocardial infarction, and non-sterile, as in tuberculosis). How such a diverse array of stimuli can converge on a central inflammatory mechanism (particularly in the case of the NLRP3 inflammasome) is a central question in inflammasome biology. Understanding how inflammasome signaling is regulated can help to develop means of modulating the innate immune response to many diseases.

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Education

Ph.D., Biological Design2015

Arizona State University
Dissertation: Ion Flux Regulates the Inflammasome

B.S., Biological Sciences (Genetics, Cell & Developmental Biology)2010

Arizona State University
Barrett Honors Thesis: Automated Confocal Microscopy Assay: Studying Heterogeneity and Toxic Variability in Neoplastic Progression of Barrett's Esophagus Cells
Summa Cum Laude

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Professional Experience

Visiting Scholar, Lab of Dr. Alfred Lewin2017

University of Florida, Department of Molecular Genetics & Microbiology

Postdoctoral Research Associate, Lab of Dr. Alexandra Lucas2017-Present

Arizona State University, The Biodesign Institute
Virginia G. Piper Center for Personalized Diagnostics

Postdoctoral Research Fellow, Lab of Dr. Vijay Singh2015-2017

Mayo Clinic, Arizona, Departments of Research, Medicine and Gastroenterology

Graduate Research Associate2010-2015

Arizona State University, The Biodesign Institute
Center for Biosignatures Discovery Automation

Student Researcher2010

University of Washington, R/V Thomas G. Thompson
Enlighten 2010 Deep Sea Expedition

Undergraduate Research Assistant2009

Arizona State University, The Biodesign Institute
Center for Ecogenomics

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Publications

Most recent first; Asterisks indicate co-first author.

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Book Chapters

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Patents

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Professional Memberships

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Service

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Oral Presentations

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